IVF

In Vitro Fertilization (IVF)

At Main Line Fertility, we understand that every journey to parenthood is unique. In vitro fertilization (IVF) is a proven and effective assisted reproductive technology (ART) that has helped countless families grow. IVF involves carefully retrieving eggs, combining them with sperm in our advanced laboratory, and transferring the resulting embryo(s) to the uterus. This process offers hope and possibility to those facing fertility challenges, and our compassionate team is here to support you every step of the way.

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Who Is IVF Right for?

As the most advanced and effective fertility treatment available today, IVF helps people from all walks of life achieve their family-building goals. IVF is often recommended to patients experiencing a wide range of fertility and reproductive challenges, including: 

Additionally, other factors that might contribute to your decision to proceed with IVF are:

  • You and your partner both have uteruses and would both like to have a biological connection to the pregnancy, also known as reciprocal IVF.
  • You’d like to use eggs frozen during fertility preservation.
  • Your partner produces sperm but has low sperm count, poor sperm motility, and/or abnormal sperm morphology.

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The IVF Process

At Main Line Fertility, we want you to know exactly what to expect from every part of your journey with us. Each of us knows personally how hard it can be to venture into the world of family-building; we will make sure that you know exactly how long things will take, how much it will cost, and what the rates of success are.

One IVF cycle takes about six to eight weeks from start to finish. Here are the steps you can expect.

  • You and your partner(s) (if applicable) will meet with your fertility specialist for fertility testing and a personalized discussion of your fertility health and family planning goals. Together, you will decide if IVF is the right choice for you and create a personalized treatment plan.

  • Over a period of 9-12 days, we will stimulate your ovaries with self-administered injections. These injections utilize a thin needle (similar to what a diabetic might use for insulin shots) and are given subcutaneously, which means below the skin (as opposed to in the muscle). You will also have approximately five to seven early morning monitoring appointments to assess whether the injections are working.

  • Once monitoring shows that your eggs have matured, you’ll visit our on-site surgery center for egg retrieval. During this quick, painless procedure, your doctor will use ultrasound guidance to gently insert a needle attached to a catheter through your vaginal wall to collect your eggs. The procedure takes 10-20 minutes under twilight anesthesia, and most patients don’t even remember it. You can bring a partner or friend for support, and there are no stitches or scars. Many patients feel well enough to return to work the next day.

    On the same day as egg retrieval, sperm collection will take place. If you’re using a partner’s fresh sperm, they will provide a sample at our clinic, ensuring the highest quality for fertilization. For those using frozen sperm, the sample will be carefully thawed in our laboratory to preserve its viability. In cases where donor sperm is being used, we coordinate closely with donor sperm banks to ensure the sample is ready for this important step.

    Whether you’re using partner sperm or donor sperm—fresh or frozen—our team will guide you through every aspect of the process to ensure everything is prepared seamlessly for fertilization.

  • In our state-of-the-art laboratory, our highly experienced embryologists will oversee the process of the sperm fertilizing the egg. Some patients will benefit from the use of intracytoplasmic sperm injection (ICSI) and/or ZyMōt sperm separation device during this step of the process

  • Over a 3 to 7-day process, our embryologists oversee the growth of your embryo(s). Some patients will benefit from preimplantation genetic testing (PGT) after this step of the process. PGT involves taking a small sample of cells from the outer layer of the embryo, freezing the embryo, and testing the cells for genetic or chromosomal abnormalities, depending on your needs. PGT does not harm the embryo in any way – the cells that are removed are taken from the part of the embryo that eventually becomes the placenta. The cells that eventually become the baby remain untouched. Once testing is complete, the frozen embryo can be thawed and prepared for transfer. 

  • During embryo transfer your doctor will insert a speculum into the vagina. Using an ultrasound for accuracy, the doctor will then pass a catheter through the cervix and into the womb. The embryos are then passed through the catheter. The entire process is a short, pain-free procedure.

IVF With ICSI

Intracytoplasmic sperm injection (ICSI) involves injecting a single live sperm directly into the center of a human egg. This procedure overcomes many of the barriers to fertilization and allows patients a better chance of obtaining fertilized embryos. ICSI procedures are performed in-house at Main Line Fertility’s state-of-the-art laboratory by our highly experienced embryologists.

Patients who may benefit From ICSI include:

  • Patients with severe male factor infertility
  • Patients who have had failure to fertilize in previous IVF attempts
  • Patients who wish to do PGT

How Many IVF Cycles Should I Expect?

When it comes to any fertility process, there are so many variables at play (age, hormone levels, other medical considerations), so we can’t say exactly how long it will take for any one person to conceive. But when it comes to IVF, there are some specific things we know:

  • On average, a single IVF cycle has between a 28-48% chance of resulting in successful pregnancy and live birth (compared to up to 20% per cycle with IUI).
  • It is generally recommended that families trying to conceive plan for three to four IVF cycles.
  • The chances of a successful pregnancy and live birth continue to increase with multiple cycles.
  • With egg and embryo freezing, multiple IVF cycles can be completed with a single egg retrieval.

IVF Using Fresh vs. Frozen Eggs, Sperm, and Embryos

When proceeding with IVF, there are several decisions to make regarding sperm, eggs, and embryos. Often, your choice of whose eggs and sperm you will use – your own, a known donor’s, or an unknown donor’s – will be the most important factor in whether you use fresh or frozen genetic material. However, there are some benefits and drawbacks to each of these decisions.

Fresh vs. Frozen Sperm

There is no difference in the likelihood of conception when using fresh or frozen sperm for IVF.

If you’re working with a partner or a known donor, such as a friend or someone you have met for the express purpose of utilizing them as a donor, you may be able to use their sperm without it being frozen first. This could be slightly more cost-effective. However, fresh sperm dies quickly; if utilizing fresh sperm, fertilization must happen quickly.

If you’re working with a partner’s previously frozen sperm sample or a sample from a donor found through a cryobank, you will be using a sample that has been collected in a clinic, washed to remove the semen, frozen, and stored at subzero temperature. Frozen sperm can be more expensive than fresh sperm, but it has the benefit of already being analyzed for concentration, volume, and morphology.

Fresh vs. Frozen Eggs

When planning your IVF cycle, you’ll decide whether to use fresh or frozen eggs. Each option has its benefits: fresh eggs generally have a slightly higher conception rate, while frozen eggs still offer excellent success rates with greater flexibility.

If you’re using your own eggs, your partner’s eggs, or eggs from a donor, fresh eggs may be an option. However, using fresh donor eggs or eggs from a partner requires syncing the cycle of the egg provider and the person who will carry the pregnancy. This process can add complexity and may require careful coordination. Alternatively, you might choose to freeze eggs during retrieval for use in multiple IVF cycles, though this involves additional storage costs.

Frozen eggs are often used when the eggs are from fertility preservation, a previous egg retrieval, or an unknown egg donor. This option eliminates the need to synchronize cycles, streamlining the IVF process while maintaining strong success rates.

Our team will help you navigate the decision between fresh and frozen eggs, ensuring that your approach aligns with your unique circumstances and goals.

Fresh vs. Frozen Embryos

Recent advancements have shown that frozen embryo transfers (FET) can offer implantation and pregnancy rates comparable to, or even higher than, fresh embryo transfers, depending on individual circumstances. For individuals undergoing their first round of IVF, the choice between fresh and frozen embryos often depends on factors like ovarian response, uterine environment, and personal preferences.

Frozen donated embryos or embryos from a previous IVF or INVOCELL cycle are carefully thawed before implantation, maintaining their viability and potential for a successful transfer.

LGBTQ+ Family Building Through IVF at Main Line Fertility

At Main Line Fertility, we are proud to support LGBTQ+ aspiring parents on their family-building journeys. We believe that every family is unique and deserving of compassionate, personalized care. Inclusivity is not just a value we embrace – it’s a commitment we make every day. From the language we use to the resources we provide, our team is dedicated to creating an environment where you feel seen, respected, and empowered.

Whether you’re considering IVF, using donor eggs or sperm, or exploring other family-building options, we’re here to guide and support you with sensitivity and understanding. At Main Line, we don’t just welcome LGBTQ+ families; we celebrate them.

How Much Does IVF Cost?

Fertility care can be expensive and for many patients, the cost of treatment can be a significant hurdle. The actual cost of fertility treatment is based on several factors, including your fertility goals, treatment plan, insurance coverage, and prescription benefits.

At Main Line Fertility, we offer fertility care financing, discount programs, prescription assistance, and clinical research trial opportunities to make care accessible for more patients. We also have partnered with BUNDL Fertility, a program that combines multiple IVF cycles into one package with a discounted, upfront cost. BUNDL offers several options for all budgets, including packages with money-back guarantees.

How Can Partners Be Involved in the IVF Process?

At Main Line Fertility, we encourage partners to play an active and supportive role in the IVF journey. Fertility treatment can be an emotional and physical process, and having a partner’s involvement can make a meaningful difference.

Partners can provide support in many ways: offering emotional encouragement, being present during key appointments, or simply helping to manage the logistics of treatment. Practical contributions like scheduling appointments, picking up medications, or assisting with injections can help lighten the load and ensure that both individuals feel equally invested in the process.

If your journey involves selecting an egg or sperm donor, partners can collaborate to make these important decisions. Sharing this responsibility can deepen your connection and create a shared sense of purpose.

For LGBTQ+ couples, there may be opportunities to explore options like reciprocal IVF, where one partner provides the eggs and the other carries the pregnancy. If both partners have uteruses, it can be helpful for both to undergo fertility evaluations to better plan your path forward.

At every stage, clear communication is key. Talk to your partner about the kind of support you need – whether it’s practical, emotional, or a combination of both. Fertility care is a team effort, and together, you can navigate this journey with strength and understanding.

Schedule a Consult for In Vitro Fertilization (IVF) in the Philadelphia Area

The fertility specialists of Main Line Fertility are proud to offer a wide range of fertility care services in Pennsylvania to meet every patient’s need, including in vitro fertilization (IVF). Connect with Main Line Fertility today to schedule a consultation by filling out our online form or contact us directly at one of our fertility clinics in Philadelphia, Bryn Mawr, West Chester, Havertown, Reading, or Fort Washington, PA.

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